Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.

Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA precatenation formed. Although fork rotation predominates at replication termination, in vitro studies have suggested that it also occurs freq...

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability